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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM310195
Substrate
n/a
Meas. Tech.
Assay for IDO1 Enzymatic Activity Determination
IC50
200±n/a nM
Citation
 Kraus, M; Cauwenberghs, S; Crosignani, S; Driessens, G Combinations comprising a pyrrolidine-2,5-dione IDO1 inhibitor and an anti-body US Patent  US10945994 Publication Date 3/16/2021 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
46214.94
Organism:
Dog
Description:
A0A8C0MXE9
Residue:
407
Sequence:
MEDDGILLMESPQRIFEKYHIDEEMGFALPNPLEKLPPPYDEWISIAKNLPELIKKNELRKKVDELKILSIDGLSGHKLQRLARLALGYITMAYVWNQGDGDVRKVLPQNIAIPYCELSEKLGLPPILVYADCVLANWKKKDPNGPMTYENMDILFWFPGGDCSKGFFLVSLLVELAAASAIKVIPNLLKAVKNQDEVTLKKALHYIASCLHRAHKEFEEVHKHVDPSTFFKVLRIYLSGWKGNSKLPEGLKYEGFWENPKEFAGGSAAQSSIFQCFDILLGIQQCSGEEFAAEFLQEMRNYMPPAHRDFLLLLKSGPSVREFVRSRDDVELKADYNECVKAMVSLRKYHLKIVAKYIVIPASQQPKNNQASEESSEQKNKGTGGTNAMDFLKSVRTTTEKFLLIDH
  
Inhibitor
Name:
BDBM310195
Synonyms:
(-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,5-dione | US10945994, Compound 2 | US9603836, Compound 2 | US9949951, 2
Type:
Small organic molecule
Emp. Form.:
C12H9FN2O2
Mol. Mass.:
232.2105
SMILES:
Fc1ccc2[nH]cc([C@H]3CC(=O)NC3=O)c2c1 |r|
Structure:
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