Reaction Details Report a problem with these data
Target
Tryptophan 2,3-dioxygenase
Ligand
BDBM310197
Substrate
n/a
Meas. Tech.
Assay for IDO1 Enzymatic Activity Determination
IC50
>50000±n/a nM
Citation
 Kraus, M; Cauwenberghs, S; Crosignani, S; Driessens, G Combinations comprising a pyrrolidine-2,5-dione IDO1 inhibitor and an anti-body US Patent  US10945994 Publication Date 3/16/2021 
Target
Name:
Tryptophan 2,3-dioxygenase
Synonyms:
T23O_MOUSE | TO | TRPO | Tdo | Tdo2 | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase
Type:
PROTEIN
Mol. Mass.:
47757.90
Organism:
Mus musculus
Description:
ChEMBL_1452150
Residue:
406
Sequence:
MSGCPFAGNSVGYTLKNVSMEDNEEDRAQTGVNRASKGGLIYGNYLQLEKILNAQELQSEVKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVIARMHRVVVIFKLLVQQFSVLETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQSLRVPYNRKHYRDNFGGDYNELLLKSEQEQTLLQLVEAWLERTPGLEPNGFNFWGKFEKNILKGLEEEFLRIQAKTDSEEKEEQMAEFRKQKEVLLCLFDEKRHDYLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMLGTKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLVPRHWVPKMNPIIHKFLYTAEYSDSSYFSSDESD
  
Inhibitor
Name:
BDBM310197
Synonyms:
US10945994, Compound 2a | US9603836, Compound 2a | US9949951, 2a
Type:
Small organic molecule
Emp. Form.:
C12H9FN2O2
Mol. Mass.:
232.2105
SMILES:
Fc1ccc2[nH]cc([C@@H]3CC(=O)NC3=O)c2c1 |r|
Structure:
Search PDB for entries with ligand similarity: