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Target
Nuclear receptor subfamily 1 group I member 2
Ligand
BDBM429639
Substrate
n/a
Meas. Tech.
PXR BINDING ASSAY
IC50
180±n/a nM
Citation
 Chen, T; Lin, W; Wang, Y 1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor US Patent  US10947203 Publication Date 3/16/2021 
Target
Name:
Nuclear receptor subfamily 1 group I member 2
Synonyms:
NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1
Type:
Nuclear receptor
Mol. Mass.:
49774.77
Organism:
Homo sapiens (Human)
Description:
O75469
Residue:
434
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
  
Inhibitor
Name:
BDBM429639
Synonyms:
US10550091, No. LC-48 | US10947203, No. LC-48
Type:
Small organic molecule
Emp. Form.:
C21H25ClN4O
Mol. Mass.:
384.902
SMILES:
COc1ccc(Cl)cc1-n1nnc(N(C)c2ccc(cc2)C(C)(C)C)c1C
Structure:
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