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Target
Beta-secretase 2
Ligand
BDBM486437
Substrate
n/a
Meas. Tech.
In Vitro Enzymatic BACE1 and BACE2 FRET (Fluorescence Resonance Energy Transfer) Assays
IC50
17.0±n/a nM
Citation
 Allen, JR; Bourbeau, MP; Chen, N; Frohn, MJ; Harrington, PE; Liu, Q; Reeves, C Substituted oxazines as beta-secretase inhibitors US Patent  US10947223 Publication Date 3/16/2021 
Target
Name:
Beta-secretase 2
Synonyms:
BACE2_MOUSE | Bace2 | Beta-secretase 2 (BACE2)
Type:
Enzyme
Mol. Mass.:
55787.27
Organism:
Mus musculus (Mouse)
Description:
Q9JL18
Residue:
514
Sequence:
MGALLRALLLLVLAQWLLSAVPALAPAPFTLPLQVAGATNHRASAVPGLGTPELPRADGLALALEPVRATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVQILVDTGSSNFAVAGAPHSYIDTYFDSESSSTYHSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESENFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQNLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRDENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQRRVGFAVSPCAEIEGTTVSEISGPFSTEDIASNCVPAQALNEPILWIVSYALMSVCGAILLVLILLLLLPLHCRHAPRDPEVVNDESSLVRHRWK
  
Inhibitor
Name:
BDBM486437
Synonyms:
(2R,5R)-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-2,5-dimethyl-2-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine | US10947223, Example 103
Type:
Small organic molecule
Emp. Form.:
C20H17ClF5N3O
Mol. Mass.:
445.813
SMILES:
C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F |r,c:7|
Structure:
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