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Target
PAS domain-containing serine/threonine-protein kinase [879-1323]
Ligand
BDBM487216
Substrate
n/a
Meas. Tech.
Kinase Luminescence Assay
IC50
<10000±n/a nM
Citation
 McCall, JM; Kelly, RC; Romero, DL Heterocyclic compounds for the inhibition of pask US Patent  US10953012 Publication Date 3/23/2021 
Target
Name:
PAS domain-containing serine/threonine-protein kinase [879-1323]
Synonyms:
KIAA0135 | PAS domain-containing serine/threonine-protein kinase (PASK) (879-1323) | PASK | PASK_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49711.83
Organism:
Homo sapiens (Human)
Description:
aa 879-1323
Residue:
445
Sequence:
MRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCLHPGDPRLLTS
  
Inhibitor
Name:
BDBM487216
Synonyms:
3-(4-Fluoro-phenyl)-5-(4-methoxy-phenyl)-2-methyl-4H-pyrazolo[1,5-a]pyrimidin-7-one | US10953012, Example 38
Type:
Small organic molecule
Emp. Form.:
C20H16FN3O2
Mol. Mass.:
349.3583
SMILES:
COc1ccc(cc1)-c1cc(=O)n2nc(C)c(-c3ccc(F)cc3)c2[nH]1
Structure:
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