Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase 30
Ligand
BDBM489719
Substrate
n/a
Meas. Tech.
In vitro biochemical assay for USP30 enzyme
IC50
49.0±n/a nM
Citation
 Kluge, A; Lagu, B; Maiti, P; Panigrahi, SK USP30 inhibitors US Patent  US10968172 Publication Date 4/6/2021 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 30
Synonyms:
Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30
Type:
Protein
Mol. Mass.:
58522.90
Organism:
Homo sapiens (Human)
Description:
Q70CQ3
Residue:
517
Sequence:
MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
  
Inhibitor
Name:
BDBM489719
Synonyms:
(S)-N-(1-((5-(N-(tert- butyl)sulfamoyl)naphthalen-1- yl)amino)-1-oxo-3-phenylpropan- 2-yl)-4-fluorobenzamide | US10968172, ID # 4j
Type:
Small organic molecule
Emp. Form.:
C30H30FN3O4S
Mol. Mass.:
547.64
SMILES:
CC(C)(C)NS(=O)(=O)c1cccc2c(NC(=O)[C@H](Cc3ccccc3)NC(=O)c3ccc(F)cc3)cccc12 |r|
Structure:
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