Reaction Details Report a problem with these data
Target
Programmed cell death protein 1
Ligand
BDBM491057
Substrate
n/a
Meas. Tech.
In Vitro Activity Assay
IC50
0.0005±0 nM
Citation
 Feng, Z; Chen, X; Yang, Y; Zheng, Y; Lai, F; Ji, M; Zhou, C; Zhang, L; Wang, K; Xue, N; Li, L Nicotinyl alcohol ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof US Patent  US10975049 Publication Date 4/13/2021 
Target
Name:
Programmed cell death protein 1
Synonyms:
CD_antigen=CD279 | PD1 | PDCD1 | PDCD1_HUMAN | Programmed cell death protein 1 | Protein PD-1 | hPD-1
Type:
PROTEIN
Mol. Mass.:
31650.07
Organism:
Homo sapiens
Description:
ChEMBL_108437
Residue:
288
Sequence:
MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL
  
Inhibitor
Name:
BDBM491057
Synonyms:
N-(4-(2-bromo-3-phenylbenzyloxy)-5-chloro-2-(pyridin-3-yl-methyleneoxy)benzyl) proline | US10975049, Example 26
Type:
Small organic molecule
Emp. Form.:
C31H28BrClN2O4
Mol. Mass.:
607.922
SMILES:
OC(=O)C1CCCN1Cc1cc(Cl)c(OCc2cccc(c2Br)-c2ccccc2)cc1OCc1cccnc1
Structure:
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