Reaction Details Report a problem with these data
Target
Alpha-synuclein
Ligand
BDBM491862
Substrate
n/a
Meas. Tech.
In-Vitro Fluorescence Polarization Assay
IC50
2400±n/a nM
Citation
 Wrasidlo, W; Stocking, EM; Hall, A; Maccoss, M Bis-heteroaryl derivatives as modulators of protein aggregation US Patent  US10975066 Publication Date 4/13/2021 
Target
Name:
Alpha-synuclein
Synonyms:
NACP | PARK1 | SNCA | SYUA_HUMAN
Type:
Protein
Mol. Mass.:
14451.42
Organism:
Homo sapiens (Human)
Description:
P37840
Residue:
140
Sequence:
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
  
Inhibitor
Name:
BDBM491862
Synonyms:
US10975066, Example 66
Type:
Small organic molecule
Emp. Form.:
C23H31N5OS
Mol. Mass.:
425.59
SMILES:
CC(C)CC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(C)CC1
Structure:
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