Reaction Details Report a problem with these data
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Ligand
BDBM449698
Substrate
n/a
Meas. Tech.
AlphaLISA Assay
IC50
0.024±n/a nM
Citation
Chu, H; Guerrero, JA; Hurtley, AE; Hwang, TH; Jiang, L; Kato, D; Kobayashi, T; Knox, JE; Lazerwith, SE; Li, X; Lin, DW; Medley, JW; Mitchell, ML; Naduthambi, D; Newby, Z; Squires, NH; Tsui, VH; Venkataramani, C; Watkins, WJ; Yang, H MCL-1 inhibitors US Patent US10988451 Publication Date 4/27/2021
More Info.:
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Synonyms:
BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1 | MCL1_HUMAN | Myeloid cell leukemia 1 (Mcl-1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17896.13
Organism:
Homo sapiens (Human)
Description:
Q07820[171-327]
Residue:
157
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
Inhibitor
Name:
BDBM449698
Synonyms:
US10703733, Example 311 | US10988451, Example 311 | US11643400, Example 311
Type:
Small organic molecule
Emp. Form.:
C37H45ClF2N4O5S
Mol. Mass.:
731.292
SMILES:
CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N[C@H]2C[C@@H]2C(F)F)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3|