Reaction Details
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Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Ligand
BDBM449757
Substrate
n/a
Meas. Tech.
AlphaLISA Assay
IC50
0.031±n/a nM
Citation
Chu, H; Guerrero, JA; Hurtley, AE; Hwang, TH; Jiang, L; Kato, D; Kobayashi, T; Knox, JE; Lazerwith, SE; Li, X; Lin, DW; Medley, JW; Mitchell, ML; Naduthambi, D; Newby, Z; Squires, NH; Tsui, VH; Venkataramani, C; Watkins, WJ; Yang, H MCL-1 inhibitors US Patent US10988451 Publication Date 4/27/2021 More Info.:
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Synonyms:
BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1 | MCL1_HUMAN | Myeloid cell leukemia 1 (Mcl-1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17896.13
Organism:
Homo sapiens (Human)
Description:
Q07820[171-327]
Residue:
157
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
Inhibitor
Name:
BDBM449757
Synonyms:
US10703733, Example 376 | US10988451, Example 376 | US11643400, Example 376
Type:
Small organic molecule
Emp. Form.:
C43H56ClN5O9S
Mol. Mass.:
854.451
SMILES:
COCCOCCO[C@H]1\C=C\[C@H](OC)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)N=[S@@](=O)(C[C@H]1C)NC(=O)c1cn(C)nc1OC |r,t:9|
Structure:
