Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50382496
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
117±n/a nM
Citation
 Congreve, MS; Andrews, SP; Mason, JS; Richardson, CM; Brown, GA 1,2,4-triazine-4-amine derivatives US Patent  US10988455 Publication Date 4/27/2021 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50382496
Synonyms:
CHEMBL2024120 | US10988455, Example 1(cxciii)
Type:
Small organic molecule
Emp. Form.:
C16H11F4N5
Mol. Mass.:
349.2857
SMILES:
Cc1cc(cc(n1)C(F)(F)F)-c1nnc(N)nc1-c1ccc(F)cc1
Structure:
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