Reaction Details Report a problem with these data
Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM494497
Substrate
n/a
Meas. Tech.
Biological Assay
Ki
2.20±n/a nM
Citation
Bryan, MC; Gobbi, A; Kiefer, Jr., JR; Kolesnikov, A; Olivero, AG; Drobnick, J; Liang, J; Rajapaksa, N; Ndubaku, C; Feng, J Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators US Patent US10988478 Publication Date 4/27/2021
More Info.:
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Inhibitor
Name:
BDBM494497
Synonyms:
N-(2-(((1S,2S)-2- hydroxycyclopentyl)methyl)- 6-morpholino-1- oxoisoindolin-5- yl)pyrazolo[1,5-a] pyrimidine-3- carboxamide | US10988478, Example 559
Type:
Small organic molecule
Emp. Form.:
C25H28N6O4
Mol. Mass.:
476.5276
SMILES:
O[C@H]1CCC[C@H]1CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(cc2C1=O)N1CCOCC1 |r|