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Target
Proteinase-activated receptor 2
Ligand
BDBM429540
Substrate
n/a
Meas. Tech.
IP-One HTRF Assay
IC50
4060±n/a nM
Citation
 Cumming, JG; Wu, FX; Edman, KH; Chen, H; Brown, DG; Burli, RW; Johnstone, SD; Brown, GA; Tehan, BG; Teobald, BJ; Congreve, MS Inhibitors of protease-activated receptor-2 US Patent  US10995072 Publication Date 5/4/2021 
Target
Name:
Proteinase-activated receptor 2
Synonyms:
F2RL1 | GPR11 | PAR2 | PAR2_HUMAN
Type:
PROTEIN
Mol. Mass.:
44152.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1497756
Residue:
397
Sequence:
MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
  
Inhibitor
Name:
BDBM429540
Synonyms:
US10550089, Example 14 | US10995072, Example 64
Type:
Small organic molecule
Emp. Form.:
C14H16FN3O
Mol. Mass.:
261.2947
SMILES:
OC(c1ncc[nH]1)c1ccc(F)cc1N1CCCC1
Structure:
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