Reaction Details Report a problem with these data
Target
Protein-lysine 6-oxidase
Ligand
BDBM469033
Substrate
n/a
Meas. Tech.
LOX Enzyme Activity Assay
IC50
1200±n/a nM
Citation
 Springer, C; Marais, R; Niculescu-Duvaz, D; Leung, L; Smithen, D; Callens, C; Tang, H Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer US Patent  US10995088 Publication Date 5/4/2021 
Target
Name:
Protein-lysine 6-oxidase
Synonyms:
LOX | LYOX_HUMAN | Lysyl oxidase | alpha-Glucosidase (alpha-Glu)
Type:
PROTEIN
Mol. Mass.:
46954.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_306619
Residue:
417
Sequence:
MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSLGSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPTARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY
  
Inhibitor
Name:
BDBM469033
Synonyms:
US10807974, Example 44 | US10995088, Example 44 | US11608330, Example 44
Type:
Small organic molecule
Emp. Form.:
C22H23FN2O5S3
Mol. Mass.:
510.622
SMILES:
NCc1ccc(s1)S(=O)(=O)c1cccc(c1)S(=O)(=O)N1CCC[C@H]1COc1ccc(F)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: