Reaction Details
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Tyrosine-protein kinase JAK1 [850-1154]
Ligand
BDBM103731
Substrate
n/a
Meas. Tech.
JAK1 Inhibition Assay
IC50
1450±n/a nM
Citation
Menet, CJ; Smits, KK Compound useful for the treatment of degenerative and inflammatory diseases US Patent US11000528 Publication Date 5/11/2021 More Info.:
Target
Name:
Tyrosine-protein kinase JAK1 [850-1154]
Synonyms:
JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 (850-1154)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
34949.64
Organism:
n/a
Description:
aa 850-1154
Residue:
305
Sequence:
EQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
Inhibitor
Name:
BDBM103731
Synonyms:
US10206907, Compound 129 | US11000528, Cpd # 5 | US8563545, 5
Type:
Small organic molecule
Emp. Form.:
C20H21N5O2
Mol. Mass.:
363.413
SMILES:
O=C(Nc1nc2cccc(-c3ccc(cc3)N3CCOCC3)n2n1)C1CC1
Structure:
