Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase JAK2 [808-1132]
Ligand
BDBM103731
Substrate
n/a
Meas. Tech.
JAK2 Inhibition Assay
IC50
1760±n/a nM
Citation
 Menet, CJ; Smits, KK Compound useful for the treatment of degenerative and inflammatory diseases US Patent  US11000528 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase JAK2 [808-1132]
Synonyms:
JAK2 | JAK2_HUMAN | Janus kinase 2 (JAK2) | Tyrosine-protein kinase JAK2 | Tyrosine-protein kinase JAK2 (808-1132)
Type:
n/a
Mol. Mass.:
37984.02
Organism:
Homo sapiens (Human)
Description:
808-1132 aa of O60674
Residue:
325
Sequence:
LFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM103731
Synonyms:
US10206907, Compound 129 | US11000528, Cpd # 5 | US8563545, 5
Type:
Small organic molecule
Emp. Form.:
C20H21N5O2
Mol. Mass.:
363.413
SMILES:
O=C(Nc1nc2cccc(-c3ccc(cc3)N3CCOCC3)n2n1)C1CC1
Structure:
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