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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM497069
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
2600±n/a nM
Citation
 Jorand-Lebrun, C; Boivin, R; Johnson, T; Wang, Y; Xiao, Y; Chen, X; Linde, N; Musch, D; Kumar, D Pyrimidinone derivatives as SHP2 antagonists US Patent  US11001561 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM497069
Synonyms:
US11001561, Compound 59 | US11702392, Compound 59
Type:
Small organic molecule
Emp. Form.:
C19H22Cl2N4O2
Mol. Mass.:
409.31
SMILES:
Cc1nc(cc(=O)n1-c1cccc(Cl)c1Cl)N1C[C@H]2CC(O)C[C@@]2(CN)C1 |wU:18.19,wD:23.26,(-5.53,1.42,;-4.76,.09,;-3.22,.09,;-2.45,-1.25,;-3.22,-2.58,;-4.76,-2.58,;-5.53,-3.91,;-5.53,-1.25,;-7.07,-1.25,;-7.84,.09,;-9.38,.09,;-10.15,-1.25,;-9.38,-2.58,;-10.15,-3.91,;-7.84,-2.58,;-7.07,-3.91,;-.91,-1.25,;;1.46,-.48,;2.93,,;3.83,-1.25,;5.37,-1.25,;2.93,-2.49,;1.46,-2.02,;1.46,-3.56,;.13,-4.33,;,-2.49,)|
Structure:
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