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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM497075
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
15.0±n/a nM
Citation
 Jorand-Lebrun, C; Boivin, R; Johnson, T; Wang, Y; Xiao, Y; Chen, X; Linde, N; Musch, D; Kumar, D Pyrimidinone derivatives as SHP2 antagonists US Patent  US11001561 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM497075
Synonyms:
US11001561, Compound 63b
Type:
Small organic molecule
Emp. Form.:
C21H26Cl2N4O2
Mol. Mass.:
437.363
SMILES:
C[C@H]1OCC2(CCN(CC2)c2nc(C)n(-c3cccc(Cl)c3Cl)c(=O)c2C)[C@@H]1N |r,wU:1.0,wD:27.31,(7.31,-3.02,;5.85,-3.49,;5.37,-4.96,;3.83,-4.96,;3.36,-3.49,;2.02,-4.26,;.69,-3.49,;.69,-1.95,;2.02,-1.18,;3.36,-1.95,;-.64,-1.18,;-.64,.36,;-1.98,1.13,;-1.98,2.67,;-3.31,.36,;-4.65,1.13,;-5.98,.36,;-7.31,1.13,;-7.31,2.67,;-5.98,3.44,;-5.98,4.98,;-4.65,2.67,;-3.31,3.44,;-3.31,-1.18,;-4.65,-1.95,;-1.98,-1.95,;-1.98,-3.49,;4.6,-2.59,;4.6,-1.05,)|
Structure:
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