Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM468665
Substrate
n/a
Meas. Tech.
Human Factor D Assay
IC50
<1000±n/a nM
Citation
Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X Disubstituted compounds for treatment of medical disorders US Patent US11001600 Publication Date 5/11/2021
More Info.:
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Inhibitor
Name:
BDBM468665
Synonyms:
(2S,4R)-1-(2-(3- acetyl-5-(S- methylsulfonimidoyl)- 1H-indol-1- yl)acetyl)-N-(6- bromopyridin-2- yl)-4- fluoropyrrolidine-2- carboxamide | US10807952, Cmp No. 70 | US11001600, Cmp No. 48 | US11447465, Cmp No. T-3
Type:
Small organic molecule
Emp. Form.:
C22H22BrFN6O4S
Mol. Mass.:
565.415
SMILES:
CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccc(cc12)S(C)(=N)=O |r|