Reaction Details Report a problem with these data
Target
D(4) dopamine receptor
Ligand
BDBM466575
Substrate
n/a
Meas. Tech.
Binding Activity Assay
Ki
22.0±n/a nM
Citation
 Yoshinaga, H; Uemachi, H; Ohno, T; Besnard, J 2,6-disubstituted pyridine derivative US Patent  US11014905 Publication Date 5/25/2021 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM466575
Synonyms:
N-[2-(6-Methyl-3′,6′-dihydro[2,4′-bipyridin]-1′(2′H)-yl) ethyl]-tetrahydro-2H-pyran-4-carboxamide | US10800755, Example 29 | US11014905, Example 29
Type:
Small organic molecule
Emp. Form.:
C19H27N3O2
Mol. Mass.:
329.4366
SMILES:
Cc1cccc(n1)C1=CCN(CCNC(=O)C2CCOCC2)CC1 |t:8|
Structure:
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