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Target
D(4) dopamine receptor
Ligand
BDBM466576
Substrate
n/a
Meas. Tech.
Binding Activity Assay
Ki
14.0±n/a nM
Citation
 Yoshinaga, H; Uemachi, H; Ohno, T; Besnard, J 2,6-disubstituted pyridine derivative US Patent  US11014905 Publication Date 5/25/2021 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM466576
Synonyms:
2,2-Dimethyl-N-[2-(6-methyl-3′,6′-dihydro[2,4′-bipyridin]-1′ (2′H)-yl)ethyl]propanamide | US10800755, Example 30 | US11014905, Example 30
Type:
Small organic molecule
Emp. Form.:
C18H27N3O
Mol. Mass.:
301.4265
SMILES:
Cc1cccc(n1)C1=CCN(CCNC(=O)C(C)(C)C)CC1 |t:8|
Structure:
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