Target
D(2) dopamine receptor
Ligand
BDBM466577
Substrate
n/a
Meas. Tech.
Binding Activity Assay
Ki
0.300±n/a nM
Citation
 Yoshinaga, HUemachi, HOhno, TBesnard, J 2,6-disubstituted pyridine derivative US Patent  US11014905 Publication Date 5/25/2021 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM466577
Synonyms:
2,2-Dimethyl-N-{2-[6-(trifluoromethyl)-3′,6′-dihydro[2,4′-bipyridin]-1′ (2′H)-yl]ethyl}propanamide | US10800755, Example 31 | US11014905, Example 31
Type:
Small organic molecule
Emp. Form.:
C18H24F3N3O
Mol. Mass.:
355.3979
SMILES:
CC(C)(C)C(=O)NCCN1CCC(=CC1)c1cccc(n1)C(F)(F)F |c:12|
Structure:
Search PDB for entries with ligand similarity: