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Target
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
Ligand
BDBM498728
Substrate
n/a
Meas. Tech.
Biochemical Assay
Ki
0.410±n/a nM
Citation
 Behenna, DC; Freeman-Cook, KD; Hoffman, RL; Nagata, A; Ninkovic, S; Sutton, SC CDK2 inhibitors US Patent  US11014911 Publication Date 5/25/2021 
Target
Name:
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
Synonyms:
CDK2/CycE | CDK2/Cyclin E | CDK2/E | CDK2/E1 | Cyclin-Dependent Kinase 2 (CDK2) | Cyclin-dependent kinase 2/G1/S-specific cyclin E1 | Cyclin-dependent kinase 2/cyclin E1
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Component 2
Name:
G1/S-specific cyclin-E1
Synonyms:
CCNE | CCNE1 | CCNE1_HUMAN
Type:
Enzyme Subunit
Mol. Mass.:
47073.17
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
410
Sequence:
MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA
  
Inhibitor
Name:
BDBM498728
Synonyms:
(1S,3R)-3-(3-{[(6- methoxypyridin-3- yl)acetyl]amino}-1H-pyrazol-5- yl)cyclopentyl (cis-4- hydroxycyclohexyl)carbamate | US11014911, Example 553 | US11718603, Example 553
Type:
Small organic molecule
Emp. Form.:
C23H31N5O5
Mol. Mass.:
457.5227
SMILES:
COc1ccc(CC(=O)Nc2cc([nH]n2)[C@@H]2CC[C@@H](C2)OC(=O)N[C@@H]2CC[C@H](O)CC2)cn1 |r,wU:24.25,27.29,wD:18.21,15.15,(13.21,1.1,;11.87,1.87,;10.54,1.1,;10.54,-.44,;9.2,-1.21,;7.87,-.44,;6.54,-1.21,;5.2,-.44,;5.2,1.1,;3.87,-1.21,;2.54,-.44,;1.13,-1.06,;.1,.08,;.87,1.41,;2.38,1.09,;-1.43,-.08,;-2.2,-1.41,;-3.71,-1.09,;-3.87,.44,;-2.46,1.06,;-5.2,1.21,;-6.54,.44,;-6.54,-1.1,;-7.87,1.21,;-9.2,.44,;-10.54,1.21,;-11.87,.44,;-11.87,-1.1,;-13.21,-1.87,;-10.54,-1.87,;-9.2,-1.1,;7.87,1.1,;9.2,1.87,)|
Structure:
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