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Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500001
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
750±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500001
Synonyms:
US11021457, Compound 10
Type:
Small organic molecule
Emp. Form.:
C26H23N3O5
Mol. Mass.:
457.4779
SMILES:
O=C1N(Cc2ccc(NC=C3C(=O)CC(CC3=O)c3ccccc3)cc12)C1CCC(=O)NC1=O |(4.64,.27,;3.87,-1.06,;4.77,-2.31,;3.87,-3.56,;2.4,-3.08,;1.07,-3.85,;-.26,-3.08,;-.26,-1.54,;-1.6,-.77,;-2.93,-1.54,;-4.26,-.77,;-5.6,-1.54,;-5.6,-3.08,;-6.93,-.77,;-6.93,.77,;-5.6,1.54,;-4.26,.77,;-2.93,1.54,;-8.27,1.54,;-9.6,.77,;-10.93,1.54,;-10.93,3.08,;-9.6,3.85,;-8.27,3.08,;1.07,-.77,;2.4,-1.54,;6.31,-2.31,;7.08,-3.64,;8.62,-3.64,;9.39,-2.31,;10.93,-2.31,;8.62,-.98,;7.08,-.98,;6.31,.36,)|
Structure:
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