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Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500038
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
<50±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500038
Synonyms:
US11021457, Compound 42
Type:
Small organic molecule
Emp. Form.:
C28H26N4O6
Mol. Mass.:
514.5292
SMILES:
O=C(CNC=C1C(=O)CC(CC1=O)c1ccccc1)Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O |(-2.33,-9.85,;-1,-10.62,;-1,-12.16,;.33,-12.93,;.33,-14.47,;1.67,-15.24,;1.67,-16.78,;.33,-17.55,;3,-17.55,;4.34,-16.78,;4.34,-15.24,;3,-14.47,;3,-12.93,;5.67,-17.55,;5.67,-19.09,;7,-19.86,;8.34,-19.09,;8.34,-17.55,;7,-16.78,;.33,-9.85,;.33,-8.31,;-1,-7.54,;-1,-6,;.33,-5.23,;1.67,-6,;3.13,-5.53,;3.9,-4.19,;4.04,-6.77,;3.13,-8.02,;1.67,-7.54,;5.58,-6.77,;6.35,-5.44,;7.89,-5.44,;8.66,-6.77,;10.2,-6.77,;7.89,-8.11,;6.35,-8.11,;5.58,-9.44,)|
Structure:
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