Reaction Details Report a problem with these data
Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500045
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
<50±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500045
Synonyms:
US11021457, Compound 49
Type:
Small organic molecule
Emp. Form.:
C28H24N4O7
Mol. Mass.:
528.5128
SMILES:
O=C(CNC=C1C(=O)CC(CC1=O)c1ccccc1)Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 |(-6.27,2.18,;-4.93,1.41,;-4.93,-.13,;-3.6,-.9,;-3.6,-2.44,;-2.26,-3.21,;-2.26,-4.75,;-3.6,-5.52,;-.93,-5.52,;.4,-4.75,;.4,-3.21,;-.93,-2.44,;-.93,-.9,;1.74,-5.52,;1.74,-7.06,;3.07,-7.83,;4.4,-7.06,;4.4,-5.52,;3.07,-4.75,;-3.6,2.18,;-3.6,3.72,;-4.93,4.49,;-4.93,6.03,;-3.6,6.8,;-2.26,6.03,;-.8,6.5,;-.03,7.83,;.11,5.26,;1.65,5.26,;2.42,6.59,;3.96,6.59,;4.73,5.26,;6.27,5.26,;3.96,3.92,;2.42,3.92,;1.65,2.59,;-.8,4.01,;-.03,2.68,;-2.26,4.49,)|
Structure:
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