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Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500056
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
275±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500056
Synonyms:
US11021457, Compound 60
Type:
Small organic molecule
Emp. Form.:
C45H58N10O9
Mol. Mass.:
883.0036
SMILES:
CC(C)[C@H](NC(=O)CN1CCN(CCNC=C2C(=O)CC(CC2=O)c2ccccc2)CC1)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O |r,wD:35.37,3.3,(5.74,-3.26,;4.4,-2.49,;3.07,-3.26,;4.4,-.95,;3.07,-.18,;1.74,-.95,;.4,-.18,;1.74,-2.49,;.4,-3.26,;-.93,-2.49,;-2.26,-3.26,;-2.26,-4.8,;-3.6,-5.57,;-4.93,-4.8,;-6.27,-5.57,;-7.6,-4.8,;-8.93,-5.57,;-10.27,-4.8,;-10.27,-3.26,;-11.6,-5.57,;-11.6,-7.11,;-10.27,-7.88,;-8.93,-7.11,;-7.6,-7.88,;-12.93,-7.88,;-14.27,-7.11,;-15.6,-7.88,;-15.6,-9.42,;-14.27,-10.19,;-12.93,-9.42,;-.93,-5.57,;.4,-4.8,;5.74,-.18,;7.07,-.95,;5.74,1.36,;7.07,2.13,;8.41,1.36,;8.41,-.18,;9.74,-.95,;9.74,-2.49,;11.07,-3.26,;11.07,-4.8,;12.41,-2.49,;7.07,3.67,;8.41,4.44,;5.74,4.44,;5.74,5.98,;4.4,6.75,;4.4,8.29,;5.74,9.06,;7.07,8.29,;8.54,8.77,;9.31,10.1,;9.44,7.52,;8.54,6.28,;7.07,6.75,;10.98,7.52,;11.75,6.19,;13.29,6.19,;14.06,7.52,;15.6,7.52,;13.29,8.86,;11.75,8.86,;10.98,10.19,)|
Structure:
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