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Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500059
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
750±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500059
Synonyms:
US11021457, Compound 63
Type:
Small organic molecule
Emp. Form.:
C30H23N5O7S
Mol. Mass.:
597.598
SMILES:
O=C(Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)c1cnc(NC=C2C(=O)CC(CC2=O)c2ccccc2)s1 |(-.35,-6.83,;-.35,-5.29,;.98,-4.52,;.98,-2.98,;-.35,-2.21,;-.35,-.67,;.98,.1,;2.32,-.67,;3.78,-.19,;4.18,1.29,;4.69,-1.44,;6.23,-1.44,;7,-2.77,;8.54,-2.77,;9.31,-1.44,;10.85,-1.44,;8.54,-.11,;7,-.11,;6.23,1.23,;3.78,-2.69,;4.18,-4.17,;2.32,-2.21,;-1.68,-4.52,;-3.15,-5,;-4.05,-3.75,;-3.15,-2.5,;-3.92,-1.17,;-5.46,-1.17,;-6.23,.16,;-5.46,1.5,;-3.92,1.5,;-6.23,2.83,;-7.77,2.83,;-8.54,1.5,;-7.77,.16,;-8.54,-1.17,;-8.54,4.16,;-10.08,4.16,;-10.85,5.5,;-10.08,6.83,;-8.54,6.83,;-7.77,5.5,;-1.68,-2.98,)|
Structure:
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