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Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500066
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
750±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500066
Synonyms:
US11021457, Compound 73
Type:
Small organic molecule
Emp. Form.:
C27H25N3O5
Mol. Mass.:
471.5045
SMILES:
CC(Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O)=C1C(=O)CC(CC1=O)c1ccccc1 |(2.92,-7.99,;1.58,-8.76,;.25,-7.99,;.25,-6.45,;-1.08,-5.68,;-1.08,-4.14,;.25,-3.37,;1.58,-4.14,;3.05,-3.67,;3.82,-2.33,;3.95,-4.91,;3.05,-6.16,;1.58,-5.68,;5.49,-4.91,;6.26,-3.58,;7.8,-3.58,;8.57,-4.91,;10.11,-4.91,;7.8,-6.25,;6.26,-6.25,;5.49,-7.58,;1.58,-10.3,;2.92,-11.07,;4.25,-10.3,;2.92,-12.61,;1.58,-13.38,;.25,-12.61,;.25,-11.07,;-1.08,-10.3,;1.58,-14.92,;.25,-15.69,;.25,-17.23,;1.58,-18,;2.92,-17.23,;2.92,-15.69,)|
Structure:
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