Reaction Details Report a problem with these data
Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500068
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
<50±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500068
Synonyms:
US11021457, Compound 75
Type:
Small organic molecule
Emp. Form.:
C32H27N3O5
Mol. Mass.:
533.5739
SMILES:
O=C1N(Cc2c1cccc2NC(=C1C(=O)CC(CC1=O)c1ccccc1)c1ccccc1)C1CCC(=O)NC1=O |(-4.24,7.86,;-3.77,6.39,;-4.67,5.15,;-3.77,3.9,;-2.3,4.38,;-2.3,5.92,;-.97,6.69,;.36,5.92,;.36,4.38,;-.97,3.61,;-.97,2.07,;.36,1.3,;.36,-.24,;1.7,-1.01,;3.03,-.24,;1.7,-2.55,;.36,-3.32,;-.97,-2.55,;-.97,-1.01,;-2.3,-.24,;.36,-4.86,;-.97,-5.63,;-.97,-7.17,;.36,-7.94,;1.7,-7.17,;1.7,-5.63,;1.7,2.07,;1.7,3.61,;3.03,4.38,;4.37,3.61,;4.37,2.07,;3.03,1.3,;-6.21,5.15,;-6.98,3.81,;-8.52,3.81,;-9.29,5.15,;-10.83,5.15,;-8.52,6.48,;-6.98,6.48,;-6.21,7.81,)|
Structure:
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