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Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500079
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
275±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500079
Synonyms:
US11021457, Compound 86
Type:
Small organic molecule
Emp. Form.:
C38H38N6O11
Mol. Mass.:
754.7419
SMILES:
O=C(Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)OCOC(=O)\C=C\C(=O)N1CCN(CCNC=C2C(=O)CC(CC2=O)c2ccccc2)CC1 |(-8.2,.81,;-8.2,-.73,;-9.54,-1.5,;-10.87,-.73,;-10.87,.81,;-12.2,1.58,;-13.54,.81,;-13.54,-.73,;-14.68,-1.76,;-16.17,-1.37,;-14.06,-3.17,;-14.83,-4.51,;-16.37,-4.51,;-17.14,-5.84,;-16.37,-7.17,;-17.14,-8.51,;-14.83,-7.17,;-14.06,-5.84,;-12.52,-5.84,;-12.52,-3.01,;-11.44,-4.1,;-12.2,-1.5,;-6.87,-1.5,;-5.54,-.73,;-4.2,-1.5,;-2.87,-.73,;-2.87,.81,;-1.54,-1.5,;-.2,-.73,;1.13,-1.5,;1.13,-3.04,;2.47,-.73,;2.47,.81,;3.8,1.58,;5.13,.81,;6.47,1.58,;7.8,.81,;9.13,1.58,;9.13,3.12,;10.47,3.89,;10.47,5.43,;9.13,6.2,;11.8,6.2,;13.13,5.43,;13.13,3.89,;11.8,3.12,;11.8,1.58,;14.47,6.2,;15.8,5.43,;17.14,6.2,;17.14,7.74,;15.8,8.51,;14.47,7.74,;5.13,-.73,;3.8,-1.5,)|
Structure:
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