Reaction Details Report a problem with these data
Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500137
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
<3±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500137
Synonyms:
US11021457, Compound 149
Type:
Small organic molecule
Emp. Form.:
C28H23BrN4O5
Mol. Mass.:
575.41
SMILES:
Brc1cc2cc[nH]c2cc1C1CC(=O)C(=CNc2cccc3C(=O)N(Cc23)C2CCC(=O)NC2=O)C(=O)C1 |(-5.6,-3.96,;-4.26,-4.73,;-4.26,-6.27,;-2.93,-7.04,;-2.61,-8.55,;-1.08,-8.71,;-.45,-7.31,;-1.6,-6.27,;-1.6,-4.73,;-2.93,-3.96,;-2.93,-2.42,;-4.26,-1.65,;-4.26,-.11,;-5.6,.66,;-2.93,.66,;-2.93,2.2,;-4.26,2.97,;-4.26,4.51,;-5.6,5.28,;-5.6,6.82,;-4.26,7.59,;-2.93,6.82,;-1.47,7.29,;-.7,8.62,;-.56,6.05,;-1.47,4.8,;-2.93,5.28,;.98,6.05,;1.75,4.71,;3.29,4.71,;4.06,6.05,;5.6,6.05,;3.29,7.38,;1.75,7.38,;.98,8.71,;-1.6,-.11,;-.26,.66,;-1.6,-1.65,)|
Structure:
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