Reaction Details Report a problem with these data
Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500138
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
<3±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500138
Synonyms:
US11021457, Compound 150
Type:
Small organic molecule
Emp. Form.:
C28H23ClN4O5
Mol. Mass.:
530.959
SMILES:
Clc1cccc2[nH]cc(C3CC(=O)C(=CNc4cccc5C(=O)N(Cc45)C4CCC(=O)NC4=O)C(=O)C3)c12 |(.22,-3.68,;-.18,-5.17,;.85,-6.31,;.38,-7.78,;-1.13,-8.1,;-2.16,-6.95,;-3.7,-6.95,;-4.18,-5.49,;-2.93,-4.58,;-2.93,-3.04,;-4.26,-2.27,;-4.26,-.73,;-5.6,.04,;-2.93,.04,;-2.93,1.58,;-4.26,2.35,;-4.26,3.89,;-5.6,4.66,;-5.6,6.2,;-4.26,6.97,;-2.93,6.2,;-1.47,6.67,;-.7,8.01,;-.56,5.43,;-1.47,4.18,;-2.93,4.66,;.98,5.43,;1.75,4.09,;3.29,4.09,;4.06,5.43,;5.6,5.43,;3.29,6.76,;1.75,6.76,;.98,8.1,;-1.6,-.73,;-.26,.04,;-1.6,-2.27,;-1.69,-5.49,)|
Structure:
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