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Target
Non-receptor tyrosine-protein kinase TYK2 [575-869]
Ligand
BDBM500300
Substrate
n/a
Meas. Tech.
Probe Displacement Assay
EC50
1.59±n/a nM
Citation
 Moslin, RM; Weinstein, DS; Wrobleski, ST Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses US Patent  US11021475 Publication Date 6/1/2021 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [575-869]
Synonyms:
TYK2 | TYK2_HUMAN | non-receptor tyrosine-protein kinase tyk2 (aa 575-869)
Type:
n/a
Mol. Mass.:
32945.07
Organism:
Homo sapiens (Human)
Description:
P29597[575-869]
Residue:
295
Sequence:
NLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRL
  
Inhibitor
Name:
BDBM500300
Synonyms:
US11021475, Example 102
Type:
Small organic molecule
Emp. Form.:
C22H23N9O3
Mol. Mass.:
461.4765
SMILES:
CNC(=O)c1nnc(Nc2ccc(CO)cn2)cc1Nc1cccc(-c2ncn(C)n2)c1OC
Structure:
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