Reaction Details Report a problem with these data
Target
Egl nine homolog 1
Ligand
BDBM500342
Substrate
n/a
Meas. Tech.
Effect of Compounds on Activities of HIF Prolyl Hydroxylase-2
IC50
700±n/a nM
Citation
 Liu, D; Chen, D; Deng, B; Tu, X; Fang, Z; Wu, H; Gu, D Indolizine derivatives and their application in medicine US Patent  US11021478 Publication Date 6/1/2021 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM500342
Synonyms:
US11021478, Example 68 | US11655249, Example 68
Type:
Small organic molecule
Emp. Form.:
C17H20N2O5
Mol. Mass.:
332.3511
SMILES:
C[C@H]1CC[C@]2(CC1)C(O)=C(C(=O)NCC(O)=O)C(=O)c1cccn21 |r,wU:1.0,wD:4.24,t:9,(2.15,4.62,;2.15,3.08,;3.48,2.31,;3.48,.77,;2.15,,;.82,.77,;.82,2.31,;.82,-.77,;-.52,,;.82,-2.31,;-.52,-3.08,;-.52,-4.62,;-1.85,-2.31,;-3.19,-3.08,;-4.52,-2.31,;-5.85,-3.08,;-4.52,-.77,;2.15,-3.08,;2.15,-4.62,;3.48,-2.31,;4.95,-2.79,;5.85,-1.54,;4.95,-.29,;3.48,-.77,)|
Structure:
Search PDB for entries with ligand similarity: