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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502037
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
117±n/a nM
Citation
 Di Francesco, ME; Jones, P; McAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502037
Synonyms:
2-Methyl-8-(2- ((methyl(2-(methyl- amino)ethyl)amino)- methyl)-6,7-dihydro- 4H-pyrazolo[5,1-c]- [1,4]oxazin-3-yl)-2- azaspiro[4.5]decan-1- one | US11028083, Example 31
Type:
Small organic molecule
Emp. Form.:
C21H35N5O2
Mol. Mass.:
389.5349
SMILES:
CNCCN(C)Cc1nn2CCOCc2c1C1CCC2(CCN(C)C2=O)CC1 |(7.96,-.63,;6.62,.14,;5.29,-.63,;3.96,.14,;2.62,-.63,;2.62,-2.17,;1.29,.14,;-.05,-.63,;.43,-2.1,;-.82,-3,;-.98,-4.53,;-2.38,-5.16,;-3.63,-4.25,;-3.47,-2.72,;-2.06,-2.1,;-1.59,-.63,;-2.92,.14,;-4.25,-.63,;-5.59,.14,;-5.59,1.68,;-7.05,1.2,;-7.96,2.45,;-7.05,3.69,;-7.53,5.16,;-5.59,3.22,;-4.34,4.12,;-4.25,2.45,;-2.92,1.68,)|
Structure:
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