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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502074
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
34.0±n/a nM
Citation
 Di Francesco, ME; Jones, P; McAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502074
Synonyms:
US11028083, Example 65a
Type:
Small organic molecule
Emp. Form.:
C20H36N4O
Mol. Mass.:
348.526
SMILES:
CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC(C)(COC)CC1 |r,wU:15.16,(7.44,-.39,;6.1,.38,;4.77,-.39,;3.44,.38,;2.1,-.39,;2.1,-1.93,;.77,.38,;-.56,-.39,;-.09,-1.86,;-1.33,-2.76,;-1.81,-4.23,;-3.35,-4.23,;-3.83,-2.76,;-2.58,-1.86,;-2.1,-.39,;-3.44,.38,;-4.77,-.39,;-6.1,.38,;-6.1,1.92,;-7.44,1.15,;-6.1,3.46,;-7.44,4.23,;-8.77,3.46,;-4.77,2.69,;-3.44,1.92,)|
Structure:
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