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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502084
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
47.0±n/a nM
Citation
 Di Francesco, ME; Jones, P; McAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502084
Synonyms:
US11028083, Example 70a
Type:
Small organic molecule
Emp. Form.:
C20H34N4O
Mol. Mass.:
346.5102
SMILES:
CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC2(CCCO2)CC1 |r,wU:15.16,(7.96,-.25,;6.62,.52,;5.29,-.25,;3.96,.52,;2.62,-.25,;2.62,-1.79,;1.29,.52,;-.05,-.25,;.43,-1.71,;-.82,-2.62,;-1.29,-4.08,;-2.83,-4.08,;-3.31,-2.62,;-2.06,-1.71,;-1.59,-.25,;-2.92,.52,;-4.25,-.25,;-5.59,.52,;-5.59,2.06,;-5.59,3.6,;-7.05,4.08,;-7.96,2.83,;-7.05,1.59,;-4.25,2.83,;-2.92,2.06,)|
Structure:
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