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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502095
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
53.0±n/a nM
Citation
 Di Francesco, ME; Jones, P; McAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502095
Synonyms:
US11028083, Example 75b
Type:
Small organic molecule
Emp. Form.:
C22H38N4O
Mol. Mass.:
374.5633
SMILES:
CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC2(CCC(C)(C)O2)CC1 |r,wD:15.16,(8.05,-.99,;6.71,-.22,;5.38,-.99,;4.05,-.22,;2.71,-.99,;2.71,-2.53,;1.38,-.22,;.05,-.99,;.52,-2.45,;-.72,-3.36,;-1.2,-4.82,;-2.74,-4.82,;-3.22,-3.36,;-1.97,-2.45,;-1.49,-.99,;-2.83,-.22,;-2.83,1.32,;-4.16,2.09,;-5.49,1.32,;-6.96,.84,;-7.86,2.09,;-6.96,3.34,;-8.05,4.43,;-6.56,4.82,;-5.49,2.86,;-5.49,-.22,;-4.16,-.99,)|
Structure:
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