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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502133
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
52.0±n/a nM
Citation
 Di Francesco, ME; Jones, P; McAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502133
Synonyms:
US11028083, Example 97b
Type:
Small organic molecule
Emp. Form.:
C22H38N4O2
Mol. Mass.:
390.5627
SMILES:
CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CC[C@@]2(CC(C)(C)CO2)CC1 |r,wU:19.27,wD:16.17,(4.05,-5.16,;5.38,-4.39,;5.38,-2.85,;4.05,-2.08,;4.05,-.54,;5.38,.23,;2.71,.23,;1.38,-.54,;1.93,-1.98,;.73,-2.95,;.65,-4.49,;-.72,-5.19,;-2.01,-4.35,;-1.93,-2.81,;-.56,-2.11,;-.16,-.63,;-1.49,.14,;-1.49,1.68,;-2.83,2.45,;-4.16,1.68,;-4.16,3.22,;-5.62,3.7,;-5.23,5.19,;-6.71,4.79,;-6.53,2.45,;-5.62,1.21,;-4.16,.14,;-2.83,-.63,)|
Structure:
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