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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503309
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
200±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503309
Synonyms:
6-amino-2-[(1R)-1-amino-3,3- difluoro-8-azaspiro[4.5]-decan-8- yl]-5-(2,3-dichloro-phenyl)- pyrimidine-4-carboxamide | US11033547, Compound 8 | US11696916, Compound 8
Type:
Small organic molecule
Emp. Form.:
C20H22Cl2F2N6O
Mol. Mass.:
471.331
SMILES:
N[C@@H]1CC(F)(F)CC11CCN(CC1)c1nc(N)c(-c2cccc(Cl)c2Cl)c(n1)C(N)=O |r,wD:1.0,(6.15,.34,;5.83,-1.16,;6.86,-2.31,;6.09,-3.64,;7.58,-4.04,;5.73,-5.14,;4.59,-3.32,;4.42,-1.79,;3.09,-2.56,;1.76,-1.79,;1.76,-.25,;3.09,.52,;4.42,-.25,;.42,.52,;.42,2.06,;-.91,2.83,;-.91,4.37,;-2.24,2.06,;-3.58,2.83,;-3.58,4.37,;-4.91,5.14,;-6.25,4.37,;-6.25,2.83,;-7.58,2.06,;-4.91,2.06,;-4.91,.52,;-2.24,.52,;-.91,-.25,;-3.33,-.57,;-2.74,-1.99,;-4.87,-.57,)|
Structure:
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