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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503332
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
200±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503332
Synonyms:
2-[(4-Amino-cyclohexyl)-methyl- amino]-5-(2,3-dichlorophenyl)-6- methyl-pyrimidine-4-carboxylic acid amide | US11033547, Compound 32
Type:
Small organic molecule
Emp. Form.:
C20H24Cl2N4O
Mol. Mass.:
407.337
SMILES:
CN(C1CCC(N)CC1)c1cc(C(N)=O)c(c(C)n1)-c1cccc(Cl)c1Cl |(1.57,-1,;1.57,.54,;3.05,.94,;3.82,-.39,;5.36,-.39,;6.13,.94,;7.67,.94,;5.36,2.28,;3.82,2.28,;.03,.54,;-.74,-.79,;-2.28,-.79,;-3.05,-2.12,;-1.96,-3.21,;-4.59,-2.12,;-3.05,.54,;-2.28,1.88,;-3.05,3.21,;-.74,1.88,;-4.59,.54,;-5.36,-.79,;-6.9,-.79,;-7.67,.54,;-6.9,1.88,;-7.67,3.21,;-5.36,1.88,;-4.59,3.21,)|
Structure:
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