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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503353
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
200±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503353
Synonyms:
6-amino-2-(4-amino-4- propylpiperidin-1-yl)-5-(2,3- dichloro-phenyl)pyrimidine-4- carboxamide | US11033547, Compound 53 | US11696916, Compound 53
Type:
Small organic molecule
Emp. Form.:
C19H24Cl2N6O
Mol. Mass.:
423.339
SMILES:
CCCC1(N)CCN(CC1)c1nc(N)c(-c2cccc(Cl)c2Cl)c(n1)C(N)=O |(6.67,-.49,;5.33,-1.26,;5.33,-2.8,;4,-3.57,;4.77,-4.9,;4,-2.03,;2.67,-1.26,;1.33,-2.03,;1.33,-3.57,;2.67,-4.34,;,-1.26,;,.28,;-1.33,1.05,;-1.33,2.59,;-2.67,.28,;-4,1.05,;-5.33,.28,;-6.67,1.05,;-6.67,2.59,;-5.33,3.36,;-5.33,4.9,;-4,2.59,;-2.67,3.36,;-2.67,-1.26,;-1.33,-2.03,;-4,-2.03,;-4,-3.57,;-5.33,-1.26,)|
Structure:
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