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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503356
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
960±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503356
Synonyms:
5-(2,3-Dichloro-phenyl)-6-methyl-2- (5-methyl-hexahydro-pyrrolo[3,4- c]pyrrol-2-yl)-pyrimidine-4- carboxylic acid amide | US11033547, Compound 56 | US11696916, Compound 56
Type:
Small organic molecule
Emp. Form.:
C19H21Cl2N5O
Mol. Mass.:
406.309
SMILES:
CN1CC2CN(CC2C1)c1nc(C)c(-c2cccc(Cl)c2Cl)c(n1)C(N)=O |(7.76,.54,;6.22,.54,;5.31,-.7,;3.85,-.23,;2.39,-.7,;1.48,.54,;2.39,1.79,;3.85,1.31,;5.31,1.79,;-.06,.54,;-.83,1.88,;-2.37,1.88,;-3.14,3.21,;-3.14,.54,;-4.68,.54,;-5.45,-.79,;-6.99,-.79,;-7.76,.54,;-6.99,1.88,;-7.76,3.21,;-5.45,1.88,;-4.68,3.21,;-2.37,-.79,;-.83,-.79,;-3.14,-2.12,;-2.05,-3.21,;-4.68,-2.12,)|
Structure:
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