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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503376
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
30.0±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503376
Synonyms:
(4M)-2-(4-amino-4-methylpiperidin- 1-yl)-6-chloro-5-(2,3- dichlorophenyl)-pyrimidine-4- carboxamide | US11033547, Compound 78 | US11033547, Compound 79 | US11696916, Compound 79
Type:
Small organic molecule
Emp. Form.:
C17H18Cl3N5O
Mol. Mass.:
414.717
SMILES:
CC1(N)CCN(CC1)c1nc(Cl)c(c(n1)C(N)=O)-c1cccc(Cl)c1Cl |(-6.75,-2.4,;-5.26,-2.8,;-6.03,-4.13,;-3.92,-3.57,;-2.59,-2.8,;-2.59,-1.26,;-3.92,-.49,;-5.26,-1.26,;-1.26,-.49,;.08,-1.26,;1.41,-.49,;2.74,-1.26,;1.41,1.05,;.08,1.82,;-1.26,1.05,;.08,3.36,;-1.26,4.13,;1.41,4.13,;2.74,1.82,;2.74,3.36,;4.08,4.13,;5.41,3.36,;5.41,1.82,;6.75,1.05,;4.08,1.05,;4.85,-.28,)|
Structure:
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