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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503410
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
660±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503410
Synonyms:
(5P)-2-[(1R)-1-amino-8- azaspiro[4.5]decan-8-yl]-5-(2,3- dichlorophenyl)-6- methylpyrimidine-4-carboxamide | US11033547, Compound 113 | US11033547, Compound 114 | US11696916, Compound 114
Type:
Small organic molecule
Emp. Form.:
C21H25Cl2N5O
Mol. Mass.:
434.362
SMILES:
Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1CCC2(CCC[C@H]2N)CC1 |r,wD:25.28,(-1.22,2.85,;-1.22,1.31,;.11,.54,;.11,-1,;-1.22,-1.77,;-2.55,-1,;-3.89,-1.77,;-3.89,-3.31,;-5.22,-1,;-2.55,.54,;-3.89,1.31,;-5.22,.54,;-6.55,1.31,;-6.55,2.85,;-5.22,3.62,;-5.22,5.16,;-3.89,2.85,;-2.55,3.62,;1.45,-1.77,;2.78,-1,;4.12,-1.77,;4.12,-3.31,;4.28,-4.84,;5.78,-5.16,;6.55,-3.83,;5.52,-2.68,;5.84,-1.18,;2.78,-4.08,;1.45,-3.31,)|
Structure:
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