Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM504686
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
130±n/a nM
Citation
Walji, A; Berger, R; Stump, CA; Schlegel, KS; Mulhearn, JJ; Greshock, TJ; Wang, D; Fraley, ME; Jones, KG 3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors US Patent US11066396 Publication Date 7/20/2021
More Info.:
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
Inhibitor
Name:
BDBM504686
Synonyms:
(S)-5-(3-(pyridin-3- yl)-1,2,4-oxadiazol- 5-yl)-1-(4-(5- (trifluoromethyl)- 1,2,4-oxadiazol-3- yl)phenyl) pyrrolidin-2-one | US11066396, Example 113
Type:
Small organic molecule
Emp. Form.:
C20H13F3N6O3
Mol. Mass.:
442.3508
SMILES:
FC(F)(F)c1nc(no1)-c1ccc(cc1)N1[C@@H](CCC1=O)c1nc(no1)-c1cccnc1 |r|