| Assay Method Information | |
| | Conditioned place preference (CPP) assay |
| Description: | The mouse-center-based representative traces of vehicle-treated mice showed more activity in the food zone when compared to the ACY775-treated mice at both fed and fasting conditions, which indicated that the vehicle-treated mice show a higher interest for food compared to the ACY775-treated mice. Determination of locomotion and velocity depending on mouse-nose-based analysis showed that both vehicle- and ACY775-treated DIO mice had similar levels of locomotion and velocity levels both in fed or fasting conditions. There were no significant differences in cumulative duration that the mice spent in the dark side chambers, which contained the mimic food. Appearance frequency of the mice within the dark side chambers were also similar for both Veh- and ACY75-treated DIO mice at both fed or fasting conditions. ACY775-treated mice, compared to the vehicle-treated mice, spent significantly shorter time and had lower frequency of appearance in the food-containing white side chambers in both fed and fasting conditions. Notably, ACY775-treated mice, compared to the vehicle group, also spent significantly shorter time and displayed lower frequency of appearance in the food zone in both fed and fasting conditions in the white side chambers. |
| Affinity data for this assay | |
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