| Assay Method Information | |
| | Biological Assays |
| Description: | Compounds were tested against the Abl1 target kinase and showed potencies between 0.30 and 0.64 nanomolar, compared to nilotinib which showed a potency of 5.15 nanomolar in the same assay. When compared to nilotinib, key compounds showed similar c-Abl potency (˜10 nM vs ˜6 nM) and markedly improved hERG potency, with an exemplary compound showing greater than 22-fold decrease in off-target potency. |
| Affinity data for this assay | |
|---|---|
| If you find an error in this entry please send us an E-mail | |