| Assay Method Information | |
| | FXR Ligand-Seeking Assay |
| Description: | The assay measures ligand-mediated interaction of the SRC-1 peptide with the FXR ligand binding domain, using biotinylated FXR LBD coupled to allophycocyanin-labeled streptavidin and biotinylated SRC-1 coupled to Europium-labeled streptavidin. The EC50 values are the mean of at least two assays. Maximum percent efficacy of the test compound is relative to FXR activation via GW 4064. |
| Affinity data for this assay | |
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